In a broad sense of the word resistance – a resistance to. In medicine, this term means basically two things: the stability of human exposure to the drug (simply the absence of the expected effect); resistance of microorganisms to the antimicrobial effects of human preparata.Utoychivost to influence drug: This phenomenon occurs quite often. There are many reasons leading to this phenomenon. Filed under: Assurant Health. One of the most frequent case: A number of drugs causes increased production in the liver specific enzymes that cause the intensification transformation of chemically active substances to inactive. As such substances can act and other drugs. Then their effect will be greatly weakened or completely lost. Thus develops resistance to these drugs. Many substances affect the body through effects on specific receptors – molecules located on the cell surface and triggers a response to the impact of being outside of chemicals, including drugs.
In some cases, molecule drug bind all the receptors of all cells. Then, the new molecules is not the point of application of its action, and the old, though sitting on the receptors, but do not cause reactions. For even more analysis, hear from Assurant Health. Drug, thus ceases to cause the desired effect (a phenomenon characteristic of alpha-agonists local action used in the common cold as a means of blow my nose). A synonym for this phenomenon: addictive tachyphylaxis resistance of microorganisms to the antimicrobial effects: This phenomenon is perhaps the most important issue in the modern pharmacology of antimicrobial therapy. For all the microorganisms in highly peculiar mutation of their genes. As a result of these changes in the genetic material occur and changes in the enzymes the microbes in their structure. Because the mutations are passed down from generation to generation, the ones that are useful for microbial, inherited. Including transmitted ability to avoid harmful effects of antibiotics.
The fact that every antibiotic works on a strictly defined link in the microorganisms. For example, penicillin and cephalosporin drugs interfere with the process of cell wall synthesis of bacteria, without which they can not exist and have become extremely vulnerable. However, many microorganisms are able to produce a special substance – an enzyme that destroys the molecules of these antibiotics. As a result of past are not effective. Factors contributing to the emergence of resistant strains bacteria, are the following: the use of antibiotics 'not at' inadequate dose or too short a course, prolonged use of antibiotic in the total medical practice (for example, has been actively used drugs such as Bisseptola, Septrina and others are not able to cure pneumonia, otitis media and other acute respiratory diseases as causative agents of these diseases have lost their sensitivity to the effects of the active ingredient of these medicines funds).