Vitamins

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Peak concentrations aminoglycosides varies between different patients, because they depend on the volume of distribution. The volume of distribution, in turn, depends on body weight, fluid volume and adipose tissue of the patient. For example, patients with extensive burns, ascites volume of distribution of aminoglycosides is increased. On the contrary, dehydration, or muscular dystrophy, it decreases. Aminoglycosides are distributed in the extracellular fluids, including blood serum, exudate abscesses, ascitic, pericardial, pleural, synovial, peritoneal and lymphatic fluid.

Capable of creating high concentrations in organs with a good blood supply: Liver, lungs, kidneys (where they accumulate in the cortex). Low concentrations are found in sputum, bronchial secretions, bile, breast milk. Aminoglycosides are poorly through the BBB. When inflammation of the meninges, the permeability of several increases. Babies in the CSF reached a higher concentration than in adults.

Aminoglycosides are not metabolized, the kidneys by glomerular filtration as unchanged, creating a high concentration in urine. Excretion rate depends on age, renal function and patient comorbidities. In patients with fever, it may increase with decreasing kidney function slows down considerably. People elderly because of reduced glomerular filtration rate may also slow excretion. The half-life of aminoglycosides in adults with normal renal function is 2-4 hours, in the newborn – 5-8 hours in children – 2.5-4 h. In renal failure the half-life can increase up to 70 hours or more. Indications Empiric therapy (in most cases is prescribed in combination with -lactams, glycopeptides or antianaerobnymi drugs, Depending on the alleged agents): Sepsis of unknown etiology. Infective endocarditis. Post-traumatic and postoperative meningitis. Fever in neutropenic patients. Nosocomial pneumonia (including ventilation). Pyelonephritis. Intra-abdominal infections. Pelvic infection. Diabetic foot. Postoperative or post-traumatic osteomyelitis. Septic arthritis. Local therapy: eye infection – bacterial conjunctivitis and keratitis. Specific therapy: Plague (streptomycin). Tularemia (streptomycin, gentamicin). Brucellosis (streptomycin). Tuberculosis (streptomycin, kanamycin). Antibiotic prophylaxis: Decontamination bowel before elective surgery on the colon (neomycin or kanamycin in combination with erythromycin). Aminoglycosides can be used to treat community-acquired pneumonia in both outpatient and in-patient conditions. This is due to the lack of activity of this group of antibiotics for the primary causative agent – the pneumococcus. In the treatment of nosocomial pneumonia aminoglycosides administered parenterally. Intratracheal instillation aminoglycosides because of the unpredictable pharmacokinetics does not improve clinical efficacy. It is wrong for the appointment of aminoglycoside therapy, shigellosis and salmonellosis (both inside and parenterally) because they are clinically ineffective against pathogens, which are localized intracellularly. Aminoglycosides are not recommended for monotherapy staph infections, since there Other effective but less toxic drugs antistafilokokkovye. Aminoglycosides should not be used for the treatment of uncomplicated infections IMP, except in cases where the pathogen is resistant to other, less toxic antibiotics. Aminoglycosides also should not be used for local application in the treatment of skin infections due to the rapid development of resistance in microorganisms. You should avoid the use of aminoglycosides for flow-through drainage and irrigation of the abdominal cavity due to their severe toxicity. From market analysis of substances of antibiotics can be found in the report of the Academy of IKAR industrial markets "Market substances antibiotics in Russia. "

Tell a wonderful story. Once I go out of the institute on the main street. A few words about myself. I am a girl slim, nice finish college. I live with my mother, my mother is an accountant in a construction firm. In general, zheiznyu normal. So, I go down the street and coming towards me is middle-aged woman is so happy and smiling.

Comes closer stops and asks what's up at the institute, how are you my mother? And I look at it and did not understand. Before me stands a modern, beautiful young woman and asks questions as if we are familiar with. Intellectually I understand that this is probably my mom with a familiar, but I can not find out. Automatically respond to her questions, and try to remember who it. The person is young, well-groomed skin, no wrinkles, eyes shining and comes from all kind of self-confidence, her whole appearance radiates health and energy.

And suddenly I was struck by a shock. Yes this is Aunt Tanya, my mother's friend, and together they I studied in college. I like this: "Tanya's aunt, is that you can not believe that the metamorphosis has happened to you? We have not seen all year, and you become younger as 10 years. "" "Genia, all the way – says Aunt Tanya – I really changed over the last year, I'm young again! I like this: "Tanya's aunt, and what chip? Compared with the Mama You're just a young virgin, just super. " It is this: "Genia, the secret is that I was advised Photostim unique product. For a year I took two courses of the drug and this is the result before you. Besides the obvious cosmetic effect considerably strengthened and health, many were sore, I feel fine, energy to spare. " The drug acts on cellular level and is very effective, especially in terms of "female" disease (see details on). Arriving home, told my mother about the meeting with Aunt Tanya. Word for word and thought and what mom is worse? Bought Photostim, my mother also took two courses. A year passed. The result exceeded all expectations. Cosmetic effect of a stunning, 10 years is gone, wrinkles smoothed out. Mom says it's not the drug, and the surgeon without a scalpel. And my mother said that the transport and work began to catch on itself looks very interesting, even men. That's a remarkable story. A product can be ordered at Photostim or. Art. Consultant Eugene

The first subgroup – breaks down and does not deposit in the body fat, the incoming with food. Preparations of the second subgroup – this fat burners. They break down the existing fat in the body. Such preparations often contain bromelain – an enzyme secreted from the South American guarana. Preparations for outdoor use. This group includes a variety of anti-cellulite gels and creams, patches, massagers and various termopreparaty to promote break down of fats (which should be applied to problem areas in while playing sports).

Nutritional – These drugs work to alleviate diets. They contain fiber, which swells in the stomach and some substances that reduce appetite. Strong effect from this category means we should not expect, but they should be consumed with great caution. After all, if you eat them without changing eating habits – you can not only lose weight but gain weight. It should be noted that one of the most popular categories – is a means to reduce appetite. Although in reality, they are recommended for people with really heavy weights.

In use it is believed that damage to the health of the extra pounds will be many times more damage the use of medicines. If you buy these products – be sure to read the instructions. Manufacturers are required to specify the dosage and the drug, as well as be responsible for their effectiveness and security. However, this is not a panacea. Even in a developed country like the U.S., with a very serious attitude to medicine and the availability of special organizations controlling release of such products in certain pharmaceutical Drugs were found hazardous constituents, which were not specified in the instructions. Many anorectics contain sibutramine. This substance, which since 2008 has been included in the list of potent drugs, and Holiday preparations based on it can be done only on prescription. Consultation with a dietitian will not interfere in any way.